Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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2,761 – 2,775 of 3,759 results

2,761

Medchemexpress LLC Benzamide, 5-(3-azetidinylamino)-N-[(1R)-1-[3-[5-[[[(1S,3R)-3-hydroxycyclopentyl)amino]methyl]-2- | 2817811-16-6 | C29H36N4O2S | 200 MG

XR8-89 is a potent papain-like protease (PLpro) inhibitor with an IC50 value of 0.1 μM. This compound induces conformational changes in SARS-CoV-2 papain-like protease, effectively inhibiting SARS-CoV-2 replication, making it suitable for research applications.

Potent papain-like protease (PLpro) inhibitor
IC50 value of 0.1 μM against papain-like protease
Induces conformational changes in SARS-CoV-2 papain-like protease
Inhibits SARS-CoV-2 replication
For SARS-CoV-2 research use
Purity of 97.13%
Appears as a light yellow to yellow solid

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2,762

Apexbio Technology LLC Kobe0065 436133-68-5 200mg

Kobe0065 (CAS 436133-68-5) is a small-molecule inhibitor targeting Ras proteins by disrupting the interaction between GTP-bound H-Ras or M-Ras and the Ras-binding domain of c-Raf-1 Identified via in silico screening Kobe0065 inhibits H-Ras GTP c-Raf-1 binding with a Ki of 46 M In NIH 3T3 cells it decreases the association of mutant H-RasG12V with c-Raf-1 in a dose-dependent manner (IC50 10 M) and suppresses downstream phosphorylation of MEK and ERK at 20 M In colony formation assays Kobe0065 inhibits proliferation of H-rasG12V transfected NIH 3T3 cells (IC50 0 5 M) and demonstrates activity against Ras-mutant cancer cell lines In xenograft models administration reduces tumor growth Kobe0065 serves as a research tool for studying Ras-mediated signaling and potential anti-tumor mechanisms

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2,763

AARON CHEMICALS LLC

NC3973187 1-CHLOROMETHYL-4-FLUORO-14-DI

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2,764

Apexbio Technology LLC Cilomilast 153259-65-5 200mg

Cilomilast (CAS 153259-65-5) also known as SB-207499 or Ariflo is a second-generation phosphodiesterase-4 (PDE4) inhibitor By selectively inhibiting PDE4 the compound increases intracellular cAMP levels affecting signaling pathways that modulate inflammatory cell function and promote airway smooth muscle relaxation Cilomilast has been shown to suppress the release of pro-inflammatory mediators such as TNF- IL-8 and GM-CSF as well as reduce neutrophil infiltration and leukotriene B4 production It is primarily investigated for its anti-inflammatory properties in research related to chronic obstructive pulmonary disease (COPD) and other inflammatory airway disorders

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2,765

eMolecules ChemScene / 4-Bromo-2-chloro-5-(difluoromethyl)pyridine / 100mg / 714105367 / CS-0498399 / 0.000 / 1471259-57-0 / MFCD25477654 / 242.450 / C6H3BrClF2N

ChemScene / 4-Bromo-2-chloro-5-(difluoromethyl)pyridine / 100mg / 714105367 / CS-0498399 / 0.000 / 1471259-57-0 / MFCD25477654 / 242.450 / C6H3BrClF2N

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2,766

Cayman Chemical Propidium Iodide Solution

PI binds to double-stranded DNA and RNA after cells have been permeabilized. Once bound to nucleic acids, the nuclei appear red in color as observed by fluorescence microscopy with a rhodamine filter. PI is useful for multi-color fluorescent staining analysis. The bright red staining of nuclei makes this an excellent counter stain to be used simultaneously with FITC, PE, or Cy5. For analysis by flow cytometry, PI staining can be monitored in the FL2 channel. PI can also be used to measure cell viability since this dye is excluded from viable cells.

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2,767

Medchemexpress LLC Amino-PEG12-amine | 361543-12-6 | 99.9% | 588.73 | 500 MG

Amino-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

PEG-based PROTAC linker
Used in the synthesis of PROTACs
Leverages the intracellular ubiquitin-proteasome system
Selectively degrades target proteins

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2,768

Medchemexpress LLC 5'-O-(4,4'-Dimethoxytrityl)-5-methoxyuridine | 2095417-73-3 | C31H32N2O9 | 100 MG

5'-O-(4,4'-Dimethoxytrityl)-5-methoxyuridine is a purine nucleoside analog known for its broad antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action includes the inhibition of DNA synthesis and the induction of apoptosis.

Purine nucleoside analog
Exhibits broad antitumor activity
Targets indolent lymphoid malignancies
Inhibits DNA synthesis
Induces apoptosis

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2,769

Medchemexpress LLC Pyrroloquinoline quinone-13C3 sodium | 72909-34-3 | 99.3% | 421.11 g·mol⁻¹ | C1113C3H2N2Na4O8 | 1 MG

Pyrroloquinoline quinone-13C3 sodium is the 13C3 isotopically labeled sodium salt of pyrroloquinoline quinone, supplied as a high-purity tracer and internal standard for quantitative analytical methods. It is intended for research use in studies of redox chemistry and biological activity, and for method development and validation in mass spectrometry and NMR-based assays.

Isotopically labeled sodium salt for tracer and internal standard use.
High purity suitable for quantitative analytical methods.
Compatible with NMR, GC-MS, and LC-MS workflows.
Supports studies of redox activity and biological function.
Supplied in small, weighed quantities for research applications.

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2,770

Medchemexpress LLC Sulfo-ara-F-NMN | 1374663-29-2 | 99.36% | 352.28 | 10 MG

Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). It acts selectively by activating SARM1 and inhibiting CD38 (IC50 around 10 μM), leading to the induction of intracellular cyclic ADP-ribose (cADPR) production.

Mimics nicotinamide mononucleotide
Selectively activates SARM1
Inhibits CD38 (IC50 around 10 μM)
Induces intracellular cyclic ADP-ribose production
For research use only
Store at -20°C under nitrogen
Unstable in solutions; use freshly prepared solutions

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2,771

Apexbio Technology LLC Oltipraz 64224-21-1 200mg

Oltipraz (CAS 64224-21-1) is a small-molecule activator targeting the nuclear factor erythroid 2 related factor 2 (Nrf2) signaling pathway It is designed to induce phase II detoxifying enzymes thereby modulating cellular defense mechanisms against xenobiotic and carcinogen exposure Oltipraz exerts its biological activity primarily through upregulation of phase II enzymes including glutathione S-transferase (GST) and NAD(P)H quinone oxidoreductase (NQO1) In rat hepatocyte assays Oltipraz demonstrates enzyme induction activity with an IC50 of approximately 10 30 M Based on these pharmacological properties Oltipraz holds research potential in chemoprevention and protection against carcinogen-related toxicity by modulation of Nrf2 signaling pathways

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2,772

Medchemexpress LLC MEDCHEMEXPRESS LLC

5000669682 CINCHONIDINE STANDA 100MG

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2,773

TARGETMOL CHEMICALS INC Fluoxetine 200MG

Also available in 1 mL, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Fluoxetine (LY-110140) is a highly specific serotonin uptake inhibitor and selective 5-hydroxytryptamine (5-HT) reuptake inhibitor. Fluoxetine has antidepressant activity. Purity 99.65%

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2,774

Apexbio Technology LLC Pimobendan 74150-27-9 200mg

Pimobendan (CAS 74150-27-9) is a small molecule that acts as a selective phosphodiesterase 3 (PDE3) inhibitor exhibiting an IC50 of 0 32 M By inhibiting PDE3 activity Pimobendan modulates intracellular cyclic nucleotide levels thereby influencing cellular signaling pathways involved in cardiovascular function This compound is utilized in biomedical research to investigate PDE3-mediated mechanisms and their implications in cardiac physiology and related disease models

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2,775

Apexbio Technology LLC BMN-673 8R,9S 1207456-00-5 200mg

BMN-673 8R 9S (CAS 1207456-00-5) is an inactive stereoisomer of BMN-673 a potent poly(ADP-ribose) polymerase 1 and 2 (PARP1/2) inhibitor While BMN-673 demonstrates selective cytotoxicity toward tumor cells with deficiencies in BRCA1 BRCA2 or PTEN exploiting vulnerabilities in DNA repair pathways BMN-673 8R 9S lacks inhibitory activity This renders BMN-673 8R 9S a valuable negative control in studies investigating PARP inhibition mechanisms and differentiating on-target from off-target effects in cellular and in vivo models of DNA repair deficiency Its use supports rigorous evaluation of PARP1/2 inhibitor specificity in translational cancer research

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Quinolines and derivatives

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Medchemexpress LLC Benzamide, 5-(3-azetidinylamino)-N-[(1R)-1-[3-[5-[[[(1S,3R)-3-hydroxycyclopentyl)amino]methyl]-2- | 2817811-16-6 | C29H36N4O2S | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC Kobe0065 436133-68-5 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC Cilomilast 153259-65-5 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Amino-PEG12-amine | 361543-12-6 | 99.9% | 588.73 | 500 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 5'-O-(4,4'-Dimethoxytrityl)-5-methoxyuridine | 2095417-73-3 | C31H32N2O9 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Pyrroloquinoline quinone-13C3 sodium | 72909-34-3 | 99.3% | 421.11 g·mol⁻¹ | C1113C3H2N2Na4O8 | 1 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Sulfo-ara-F-NMN | 1374663-29-2 | 99.36% | 352.28 | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC Oltipraz 64224-21-1 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC MEDCHEMEXPRESS LLC Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

TARGETMOL CHEMICALS INC Fluoxetine 200MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC Pimobendan 74150-27-9 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC BMN-673 8R,9S 1207456-00-5 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More